Endocrine Abstracts

Introduction: The islets of pancreas contain relatively high levels of Gamma-amino butyric acid (GABA). This study was designed to determine the role of the GABA and GABAB receptor on glucose-stimulated insulin secretion of isolated islets in rats.Materials and methods: The Collagenase digestion technique was used to isolate the islets from male Wistar rats and insulin secretion was assessed in islets exposed to glucose (8.3, 16.7 mM) in prese...

Introduction: Any abnormalities during pregnancy can affect the growth and development of the fetus and may have a long lasting effect presented during adulthood (intrauterine programming). In this study, the effect of maternal hypothyroidism on insulin secretion from the isolated islets of offspring has been investigated in male rats.Materials and methods: In Test group maternal hypothyroidism was induced using 0.02% propylthiouracyl in drinking water t...